【摘要】 目的探讨宫颈炎康栓治疗宫颈高危型人乳头瘤病毒(HPV)感染及宫颈糜烂样改变的疗效。方法对2011年11月至2012年11月在西安交通大学医学院第一附属医院、第二附属医院、第四军医大学西京医院、陕西省人民医院四家医院妇科门诊确诊生殖道高危型HPV病毒感染者,同时行宫颈液基细胞学(TCT)及阴道镜检查排除宫颈癌前病变及宫颈癌的病例共205例。治疗组105例,其中有3例中途退出研究,应用宫颈炎康栓阴道用药2个月;对照组100例,不用任何药物,只进行观察。用药后,再次行宫颈分泌物HPV检查、妇科检查、TCT、白带系列、阴道镜检查评估疗效。结果治疗组用药后1、2个月高危型HPV的转阴率分别是34.3%、45.1%。年龄<35岁与≥35岁组两组间HPV高危型总转阴率差异无统计学意义。治疗组用药后2个月HPV转阴率前5位亚型分别是HPV56(71.5%),HPV39(72.8%),HPV18(71.5%),HPV31(68.5%),HPV59(66.7%)。宫颈炎康栓能有效改善宫颈糜烂样改变,总有效率为54.4%。研究中发现,宫颈炎康栓能有效地使生殖道支原体转阴,总转阴率100.0%。结论宫颈炎康栓能有效地治疗高危型HPV感染及宫颈糜烂样改变,并使生殖道支原体转阴。更多还原

【Abstract】 Objective To study the effects of Chinese medicine gongjingyankang suppository for the treatment of high-risk HPV infection and cervical erosion change. Methods 205 cases which had been diagnosed as genital tract high-risk HPV virus infections from November 2011 to November 2012 were selected from the gynecological clinic of the following hospitals : the First Hospital and the Second Hospital of Xi ’an Jiaotong University,the Fourth Military Medical University Xijing Hospital and Shanxi People’s Hospital. These cases have been ruled out CIN and cervical cancer by cervical TCT,vaginal lens check,and cervical biopsy if necessary. The treatment group,which included 105 cases at first,consists of 102 cases using gongjingyankang for 2 months. The other 100 cases in the control group are observed only. Two months later,cervical secretion HPV examination,pelvic examination,leucorrhea routine examination,cervical TCT,vaginal lens check were taken again to make sure the drug effects. Results In the treatment group,the high-risk HPV negative rate is 34. 3% and 45. 1% respectively in 1 and 2 months after treatment. Among the cases of less than 35 year-old ones and older than 35 year-old ones,high-risk HPV negative rate has no statistical difference. After treatment,the HPV subtypes with higher negative rate include HPV56 ( 71. 5% ) ,HPV39 ( 72. 8% ) ,HPV18 ( 71. 5% ) ,HPV31 ( 68. 5% ) and HPV59 ( 66. 7%) . Gongjingyankang is effective to cervical erosion change. The total effective rate is 54. 4%. We accidentally find that gongjingyankang is effective to genital tract mycoplasma infection. The total effective rate is 100. 0% . Conclusion Chinese medicine gongjingyankang can effectively turn highrisk HPV infection from positive to negative, improve the cervical erosion change,and may be effective to genital tract mycoplasma infection.更多还原