【摘要】 目的研究灯盏花素对麻醉犬稳定型劳累性心绞痛的治疗作用。方法麻醉犬狭窄冠状动脉前降支并快速起搏心脏造成稳定型劳累性心绞痛模型,用心电图ST段变化、冠脉流量及冠脉阻力等指标观察灯盏花素静脉给药对稳定型心绞痛的治疗作用。结果麻醉犬狭窄冠状动脉前降支并快速起搏心脏后,心电图ST段明显下降,硝酸甘油可明显抑制这种变化,病理模型可靠;静脉注射灯盏花素可减小快速起搏后ST段的降低程度,降低冠脉阻力。结论灯盏花素预防性给药对麻醉犬稳定型心绞痛有缓解作用。更多还原

【Abstract】 Objective To study the therapeutic effects of erigeron on a stable effort angina pectoris in dogs. Methods The dogs were subjected to left anterior descending coronary artery(LAD) stenosis to generate a stable effort angina pectoris only when the hearts were paced.The effect of erigeron was evaluated by observing changes of ST-segment on electrocardiograms,coronary flow and coronary resistance. Results ST-segment descended rapidly only when the the dogs were subjected to left anterior descending coronary artery(LAD) stenosis and hearts were paced.Nitroglycerin obviously inhibited this change.The pathological model was proved to be reliable.Erigeron injected through vein reduced ST-segment descending by pacing and lowered the coronary resistance. Conclusion Erigeron could relieve the stable effort angina pectoris in a prevention regime.更多还原