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癫痫患者及慢性癫痫大鼠脑组织生长抑素的测定及意义

Measurement and significance of somatostatin in patients with epilepsy and experimental epilepsy model

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【作者】 汪银洲阮旭中朱遂强章军建

【Author】 Wang Yinzhou,Ruan Xuzhong,Zhu suiqiang Department of Neurology,Tongji Hospital of Tongji Medical University,Wuhan,430030

【机构】 同济医科大学同济医院神经内科

【摘要】 为揭示生长抑素(SOM)与癫痫发生的关系。采用放射免疫法检测了癫痫患者脑脊液及戊四氮诱发的慢性癫痫大鼠脑组织SOM放射免疫活性。结果显示:癫痫患者脑脊液中SOM含量显著高于对照组;慢性癫痫大鼠顶叶皮层、海马内SOM含量亦显著高于对照组。提示:SOM与癫痫发作有关。

【Abstract】 In order to investigate the role of somatostatin in epilepsy,We measured somatostatin like immunoreactivity in cerebrospinal fluid of epileptic patients and in brain tissue of pentylenetctrazol induced model.The results showed that the contents of somatostatin were obviously increased with significant differece in cerebrospinal fluid of epileptic patients and hippocampus.cerebral cortex of chronic epileptic rats as compared with the control group.The results indicated that somatostatin play a very important role in the development of epilepsy.

【关键词】 戊四氮癫痫生长抑素
【Key words】 Pentylenetetrazol Epilepsy Somatostatin.
【基金】 国家自然科学基金
  • 【文献出处】 中风与神经疾病杂志 ,JOURNAL OF APOPLEXY AND NERVOUS DISEASES , 编辑部邮箱 ,1997年04期
  • 【分类号】R742.1
  • 【被引频次】3
  • 【下载频次】32
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