【作者】 李天柱；

【导师】 银路；

【作者基本信息】 电子科技大学 ， 管理科学与工程， 2010， 博士

【摘要】 20世纪是信息技术的世纪,21世纪则将是现代生物技术的世纪。大力发展现代生物技术是我国不断缩短与发达国家的差距,实现经济和技术跨越式发展的关键之一。由于现代生物技术本身所具有的许多独有特征导致了其在发展过程中将面临一系列特殊的管理问题,在生物技术产业迅猛发展的今天,深入研究有效管理现代生物技术的思路和方法,具有重要的现实意义和理论价值。本文首先分析了现代生物技术的概念和内涵,并基于现实的产业发展,系统研究了现代生物技术的形成路径与发展特征、技术自身的特征、生物技术企业的特征以及生物技术产业的特征,进而归纳了现代生物技术的管理特征。在此基础上,针对目前对现代生物技术管理研究的空白和不足,重点研究现代生物技术管理中的企业策略与产业集群发展问题。主要研究内容包括:1.从企业层面详细研究了现代生物技术的评估与选择。1)针对现代生物技术发展所具有的高度不确定性和极度模糊性、决策阶段多、发展周期长的突出特征,研究情景规划在现代生物技术动态评估中的应用;2)研究综合运用情景规划、实物期权进行现代生物技术投资决策分析;3)在技术评估和投资决策分析的基础上,提出了企业现代生物技术选择的理论框架和模型。2.进一步研究了生物技术企业发展的特殊思路。1)以当前现代生物技术应用的最成熟的生物制药产业为背景,研究了生物制药企业的关键成功要素以及要素的演进,进而研究了生物技术企业的典型发展路径以及不同类型的企业采取不同发展路径的原因;2)针对生物技术企业研发活动的密集性、风险性及研发过程中面临的高度不确定性,提出了研发柔性的概念,结合现代生物技术研发的特点,研究了提高和保持生物技术企业研发柔性的具体思路和措施;3)提出了“技术创新成功中的导火索事件”的概念,归纳分析了“导火索事件”的类型及其对现代生物技术创新成功的作用,并分析如何挖掘和利用“导火索事件”,以加速现代生物技术商业化的进程。3.详细研究了生物技术产业集群发展。1)针对现代生物技术创新的独特模式和内在规律,分析了现代生物技术创新的两股关键力量(专家型公司与核心公司)及生物技术创新的可持续性;2)生物技术产业发展的主要特征是集聚化发展,研究了生物技术产业集群的动力机制及其演进,并抽象归纳了集群发展的特殊规律;3)在定义集群持续创新的基础上,进一步总结分析了生物技术产业集群的持续创新网络与持续创新机理。最后,通过总结归纳前述各章的研究,分别从企业和产业两个层面提出我国发展现代生物技术的对策建议。本文创新之处在于:1)系统研究归纳了现代生物技术的相关特征,为进一步深入研究现代生物技术管理奠定了基础;2)将情景规划、实物期权两种方法应用于现代生物技术的评估与选择,对于应对现代生物技术的高度不确定性具有较强指导意义;3)提出了“技术创新成功中的导火索事件”、研发柔性、集群持续创新等若干新概念,发现了现代生物技术管理所特有一些新的现象和规律,并对它们进行了探讨;4)广泛采用理论演绎结合案例分析的研究方法,使论文的研究结论具有较强的实用性和现实指导价值。更多还原

【Abstract】 20th century was the century of information technology, and the 21st century will be the century of modern biotechnology. To shorten the gap compared with the developed countries and achieve economic and technological leap-forward development, it is important to greatly develop modern biotechnology. As the modern biotechnology itself has many unique features, the development process will be faced with a series of special management problems. Today biotechnology industry has a rapid development, so to further study the ideas and methods of effective management modern biotechnology will has important practical significance and theoretical value.This paper first analyzed the concept and connotation of modern biotechnology, and systematically studied the forming path and development characteristics of modern biotechnology, its own characteristics, the characteristics of biotechnology enterprises, as well as the characteristics of the biotechnology industry based on the reality of industrial development, thus summarized the management characteristics of modern biotechnology. On this basis, according to the blank and deficiency of study, this paper mainly studied the problems of enterprises tactics and industry clusters development in modern biotechnology management.The main results are as follows:1. This paper studied the evaluation and selection of modern biotechnology from the firm level. 1) According to the outstanding characteristics of high uncertainty and utmost fuzziness, having many decision stage and long development cycle, we studied the application of scenario planning in the dynamic assessment of modern biotechnology; 2) We studied investment decision analysis of modern biotechnology integrated use scenario planning and real options; 3)We put forward the theoretical framework and model of enterprise choice based on the analysis of technology assessment and investment decisions.2. This paper studied the special thought of biotechnology enterprises development. 1) Taking biopharmaceutical industry as a background, we studied the critical success factors and their evolution of biopharmaceutical enterprises, as well as the typical development path and reasons that the different types of enterprises to adopt different development paths; 2) We put forward the concept of R&D flexibility according to the intensity risk and high uncertainty of R&D in biotechnology enterprises. Meanwhile, we also studied the specific ideas and measures that can enhance and maintain the R&D flexibility of biotechnology enterprises, bases on the characteristics of biotechnology R&D; 3) We put forward the concept of“fuse events in innovation success”, and summarized and analyzed its type, the effect to innovation success of modern biotechnology. At the same time, we also analyzed how to mine and use fuse events in order to accelerate the commercialization of modern biotechnology.3. We studied the development of biotechnology industry clusters. 1) we analyzed two key power of modern biotechnology innovation (expert-type companies and core-type companies) and the sustainability of biotechnology innovation, according to the unique pattern and inherent law of modern biotechnology innovation; 2) The main characteristics of biotechnology industry is accumulated development, so we researched the dynamic mechanism and its evolution of biotechnology industry clusters, and summed up the special law of clusters development; 3)On the basis of definition of clusters continuous innovation ,we further analyzed the continuous innovation network and the continuous innovation mechanism of biotechnology industry clusters.Finally, by summarizing the above studies, this paper put forwarded the countermeasures and suggestions for how to develop modern biotechnology from the level of enterprise and industry.This is the innovations: 1) We systematically summarized the related characteristics of modern biotechnology, and these can lay a foundation for further in-depth study of modern biotechnology management; 2) Using of scenario planning and real options to assess and choose modern biotechnology, which have strong guiding significance for cope with the high uncertainty; 3) We proposed the concepts of“fuse events in innovation success”, R&D flexibility, clusters continuous innovation. Meanwhile, we found and discussed some new phenomena and laws in modern biotechnology management; 4) We extensively use case studies with theoretical deduction, so the research conclusions have strong practical and realistic guidance value.更多还原