【作者】 伊正君；

【导师】 朱道银；

【作者基本信息】 重庆医科大学 ， 内科学， 2006， 博士

【摘要】 国内外研究背景:1.疫苗本身具有免疫预防和免疫治疗作用,疫苗进入机体后,通过诱导机体的免疫系统产生一系列免疫应答反应来发挥免疫治疗作用。当前结核病治疗性疫苗的研究主要集中在基因疫苗[1]和灭活分枝杆菌治疗性疫苗[2]两个方面,治疗性活疫苗尚未见报道。2.Mtb.是一种胞内寄生菌,细胞免疫被认为是宿主抗结核感染的主要保护机制。大量潜伏感染病例的存在[3]、多耐菌株的流行[4]、防治效果不确定[5]、再燃与复发是目前困扰结核病防治工作的几个突出问题。Mtb.的胞内持留既是潜伏感染形成的基础,也是参与多耐菌株产生以及导致治疗后再燃和复发的关键因素。3.宿主的免疫素质和免疫状态是决定感染后转归的本质因素[6],结核病患者全身整体免疫状态倾向于Th2型。由于Th2型细胞因子诱导Th0细胞向Th2细胞分化,可抑制Th1型细胞因子的产生,从而造成机体持续的细胞免疫功能低下。IL-12是一种功能强大的Th1型免疫反应诱导剂,外源给予IL-12可产生Th2免疫状态向Th1型免疫状态的逆转[7]。更多还原

【Abstract】 Background:1. Having entered in the body, the vaccines can induce immune responses for the prevention or therapy of the diseases. Currently, the researches of tuberculosis therapeutic vaccines mainly focus on gene vaccine and the killed mycobacterium vaccae vaccine .2. Cellular immunity is considered as the most important defence of the host. The introcellular persistence of the Mtb.is the key reason for the latent infection. Multidrug-resistant TB is spreading. The recrudescence and relapse of the disease always occur. These compose the most difficult problems to deal with in prevention and therapy of tubculosis.3. The prognosis of mycobacterium infection is determined by the intrinsic nature of host’s immune system. The patients with tuberculosis present Th2 immune response that restrains the producing of Th1 cytokines, thus the persistence of inefficiency in the cellular immunity of the host is formed. IL-12 is a so powerful cytokine of inducing Th1 immune response that a reversion from Th2 to Th1 would be occur when it was administered更多还原