【作者】 陈敏；

【导师】 张云亭；

【作者基本信息】 天津医科大学 ， 医学影像， 2004， 博士

【摘要】 背景：下丘脑做为机体代谢的调节中枢，其主要功能表现为对某一种物质刺激的敏感性和产生神经递质参与调节的效应性；上述重要功能迄今尚未得到充分的研究证实。fMRI是目前世界上脑科学和临床脑系科学研究最有前途的研究领域：通过fMRI，人类在科学史上第一次可以直接“看”到大脑对机体的神经调节活动；本项目将应用fMRI技术探讨不同体重者(超重者和正常体重者)下丘脑对糖耐量试验敏感性的影响；结合应用免疫组化技术研究上述变化状态下对下丘脑释放神经递质的影响，以阐明下丘脑效应性的可能变化；并建立、优化fMRI图像分析、处理的技术平台；为进一步探讨糖耐量中枢神经调节功能异常与疾病发生的关系提供直接的实验依据及技术手段。 第一部分 不同体重者葡萄糖耐量试验中枢敏感性的研究 目的 应用fMRI观察不同体重者下丘脑对口服葡萄糖耐量试验的反应，揭示不同体重者下丘脑中枢糖代谢调节的敏感性与代谢紊乱发生的关系。材料与方法分别收集10名正常体重者与10名肥胖者口服75g葡萄糖后的下更多还原

【Abstract】 Background Hypothalamus plays a central role in the regulation of body metabolism; its main function is to the sensitivity of a certain material incentive and the effect of delivering the neurotransmitters to regulate the body metabolism;Up to the present, above important function has not getten the sufficient research proof yet. The fMRJ is current the most popular and the most future investigative field in the brain science and the clinical science through the world. By fMRI, mankind first can "see" direct brain’s activity to regulate body metabolism in the science history. This research project will apply the fMRI technique to study the sensitivity of hypothalamus’s influence to glucose tolerance in different weights (the overweights and the normal weights); and combinative application of the PCR technique will be used to study the effect of above variety appearance to influence the neurotransmitter’s releasing of hypothalamus so as to clarify the possible variety of hypothalamus’s effect.The series of fMRI data analysis and data processe technique will be established and optimized in order to offer the direct experiment basis and technique means for further studying the relation between the abnormality of glucose tolerance regulated by the central nervous system and diseases.更多还原