By using chitosan as material and 1,4-dioxane as the reaction solvent,a new method to prepare carborymethylchitosan in non-proton solvent was studied.The influential factors on the substitution degree of CMC,such as alkali concentration,the ratio of reactants,reaction temperature,reaction time and amount of catalyst,were discussed..The result shows that the best reaction conditions of synthesizing high substitution degree(2.23) CMC were that the alkali concentration 35%,the ratio of chitosan to sodium chlor...