BACKGROUND & AIM: To study the acute toxicity and genotoxicity of selenium-enriched probiotics. MATERIALS AND METHODS: Acute toxicity test of mice,Ames test,micronucleus test of bone marrow PCE cell in mice, sperm abnormality test of mice were used. RESULTS: The oral acute toxicity study revealed that the LD50 of selenium-enriched probiotics was 18.49 g/kg in mice. The results of genotoxicity tests were all negative, including Ames test, micronucleus test and sperm shape abnormality test. CONCLUSION: Seleni...