Objective To investigate the role of NF-κB in induction of apoptosis of hepatocellular carcinoma cells with TRAIL. Methods Cell apoptosis, activity of NF-κB, expression of apoptosisrelated proteins in SMMC-7721 cells treated with TRAIL and/or MG-132 were determined with flow cytometry, ELISA and Western blot. Results The cell apoptosis index was significantly lower in TRAIL group than in the group of TRAIL with MG-132 treatment (15.1% vs. 27. 4%, P<0. 01). However, it was higher in the 2 groups than in the ...
【更新日期】
2007-04-13
【分类号】
R735.7
【正文快照】
研究发现，核转录因子NF-‘B可参与肿瘤细胞生长和转移的调控，然而，其在化疗药物诱导肿瘤细胞凋亡过程中，是否也参与凋亡过程的调控，从而使细胞具有药物抵抗性，目前鲜见相关报道。因此，本研究试图探讨在肿瘤坏死因子相关凋亡诱导配基(Tumor neerosis faetor related apop
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