Objective To evaluate the content,stability and release of econazole nitrate in microcapsule consisted of gelatin and acacia.Methods The content of econazole nitrate in microcapsule was determined by HPLC.The stability of the microcapsule was evaluated by classical stress test and accelerated test.The overall release rates of econazole nitrate in the suppository and microcapsule were measured by osmosis.Results The content of econazole nitrate in the microcapsule was 36.47%.It was stabile under light radiat...
【基金】
广东海洋大学校内资助项目(0312057)
【更新日期】
2006-06-05
【分类号】
TQ463.5
【正文快照】
硝酸益康唑(econazole n itrate,本文简称Ⅰ)为广谱抗真菌药,对皮肤癣菌、酵母菌、双相型真菌、曲菌等均有杀菌和抑菌作用,为临床上治疗股癣、手足癣、花斑癣、念珠菌性皮炎等浅部真菌感染疾病的首选药物,但硝酸益康唑在治疗妇科疾病如霉菌、念珠菌阴道炎等疾病时,疗效虽显著,?
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