Objective To study the therapeutic effects of oleum curcumae wenchowensis on skin of guinea pigs damage irradiated by UVB and its mechanism.Methods The skin of guinea pigs was irradiated by UVB((28.38 J·cm~(-2),)30 d) to establish the oxidative damage model.The skin erythema and the rough level were observed during the experiment;the appearance and thickness of epiderm and the number of fibroblast were observed under light microscope.The activities of GSH-Px,SOD,CAT and T-AOC and the content of MDA in the s...