采用组织细胞培养方法 ,测试了板蓝根多糖、当归多糖、黄芪多糖、黄芪皂甙、人参皂甙、淫羊藿多糖、蜂胶多糖、蜂胶黄酮、黄芪黄酮、淫羊藿黄酮共 1 0种天然药物成分在鸡胚成纤维细胞 ( CEF)体外培养中的最大安全浓度。结果表明 :黄芪多糖、当归多糖对鸡胚成纤维细胞毒性最低 ,最大安全浓度达 1 562 .5μg/ m L ,其后依次是板蓝根多糖、人参皂甙、黄芪黄酮、黄芪皂甙、蜂胶多糖、淫羊藿多糖、淫羊藿黄酮和蜂胶黄酮 ;蜂胶黄酮的毒性最大 ,其最大安全浓度仅 4.883 μg/ m L。多糖成分的毒性较黄酮成分小
【英文摘要】
The safety concentration of several components in natural drugs on chick embryo fibroblast was studied by tissue culture. These drugs and components were respectively the polysaccharides in Radix isatidis, angelicae sinensis, astragali,epimedium and propolis, the flavones in Radix astragali, epimedium and propolis, the saponins in Radix ginseng and astragali. The results showed that the safety concentration of polysaccharide in Radix astragali and angelicae was 1562.5 μg/mL and the least toxicity to chick e...