In this study, Wistar rat was used to establish a dementia model by devasculating left cortex. The expression BDNF, trkB, BDNFmRNA, and trkBmRNA decreased obviously in rat cortex and hippocampus after cortical devasculation. Congsheng capsule can increase the expression of BDNF, trkB, BDNFmRNA, and trkBmRNA obviously in rat cortex and hippocampus after cortical devasculation. Those results show that Congsheng capsule can improve the learning and memory function of rat after cortical devasculation through up...