Objective:To observe the effect of Buckthron extract on anti aging in old wistar rats. Methods:After 25 day feeding,we detected the level of LPO,SOD,GSH Px in the serum and the Lipofusin in the cerebral cortex.Results:The experiment group produced markedly decreased LPO and Lipofusin and produced markedly improved activity of SOD and GSH Px,compared with the control group.Conclusion:The Buckthron extract could decrease the lipid peroxidation in the rats.