To probe into the relation to regulation of Diabetic Neuropathy (DN) and endocrine hormone, and effects of HLS treated DN. In ratmodel using streptozotocin (STZ), nerve condution velocity (NCV) was determined by method of electrophysiology and insulin (INS), growth hormone (GH) and somatostatin (SS) levels were determined by RIA. Results showed that this drug can decrease concentration of serum glucose ( P <0.01) and GH ( P <0.05) as well as increase content of serum INS ( P <0.01) and SS ( P <0.0...