OBJECTIVE:To prepare oxaprozin gel and to establish an UV spectrophotometry for the determination of Oxaprozin gel.METHODS:The Oxaprozin gel which Carbomer 941 as excipient was prepared.An UV spectrophotometry at (287± 0.5 ) nm,for the determination of Oxaprozin in gel was established.RESULTS:The average recovery was 99.9 %, RSD was 0.61% .CONCLUSIONS:The preparation of Oxaprozin gel was simple,its quality was stable,the UV spectrophotometry for the determination was simple and rapid.