AIM: To observe the anti -hepatocirrhosis effect of Chinese herb, Ze Lan. METHODS: Hepatocirrhosis animalmodels of rats and mice were induced by subcutaneous injection of CCl4. RESULTS: Preventive administration of Ze Lanshowed anti - hepatofibrosis effect, decreased the activities of sGPT and sGOT and increased the amount of total serum proteinand albumin significantly. CONCLUSIONS: Ze Lan has satisfactory anti - hepatocirrhosis effect on experimental cirrhosis ofrats and mice.