In this paper, the effect of genotoxicity, reproductive toxicity and embryotoxicity on the second hand smoking in mice were investigated by the animal experimental model. Kunming mice were divided randomly into various experimental groups. The animals were exposed by smoke in 4.7g/m\+3\,9.4g/m\+3 and 18.8g/m\+3. The rusultes showed that the frequencies of bone marrow polychromatic erythrocytes micronucleus, bone marrow cell SCE, early spermatids MN, spermatogonia chromosome aberration and sperm aberration ...