The hypothesis of inflammatory cytokines induced by heat stroke was proposed and proven.Circulatory failure during heat stroke was found to be related toβ-endorphin.Protective drugs were also developed. Low temperature resulted in injury of vascular endothelium,enhancement of vascualr permeability and increase in tendancy of blood coagulation.The novel idea of identifying vascular endothelial cells as the target for addressing low temperature injury was proposed.This promoted the development of novel drugs....
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