Objective To investigate the inhibiting effect of total saponin on the tumor neocessel in mice.Methods After intragastric administration of total saponin for 10 days,the inhibited rate of tumor was calculated on mice. The morphologic change of tumor tissue was observed by HE staining.The apoptosis of tumor endothelial cells was detected by TUNEL method,and the protein expression of CD31,HIF-1 and FLK-1 were measured by immunocytochemical techniques.Results Compared with the model group,the tumor of mice whi...
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