The incidence and mortality rate of cancer is much higher than other diseases. New treatment agent is the focus of anticancer research, which bring us better treatment and many new side-effects compared to traditional chemotherapy. For example, delayed-onset diarrhea caused by irinotecan, peripheral neuropathy induced by oxaliplatin, hand foot syndrome caused by capacitabine and hand foot skin reaction associated with multitargeted kinase inhibitors (e.g. sorafinib, sunitinib). The mechanisms of these side-...
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