Ergosterol is the precursor of Vitamin D2,and it is an important component in fungi membrane.It is also an important raw material of medical chemistry industry and a potential anticarcinogenic drugs.Recently,in order to obtain a mass of ergosterol,many brieeding methods for high-yielding strains have been made.While the biosynthetic pathway of ergosterol has been clear,gene engineering has become an important and novel method for breeding of ergosterol high-yielding strains.This article will summarize its a...