Objective To study the compatibility and growth of osteo- blastic cells cultured with hydroxyapatite (HA) based scaffold materials and explore the feasibility of epimedium(EP) as functional scaffold mate- rials.Method Osteoblasts obtained from rat skulls were co-culturod in vitro with HA/CS,HA/CS-SF,HA/CS-SF-EP scaffolds prepared by freeze dry technique,the cell growth and attachment were observed by in- vert microscope and scanning electron microscope (SEM),in addition, the assay of MTT proliferation and a...