The progress and application of CO2 supercritical fluid (SF-CO2) in clean leather manufacture were reviewed with 26 refs. Influences of SF- CO2 to clean leather manufacture in unhairing, deliming, degreasing, chrome tanning and dyeing process were discussed respectively. Furthermore, its applications in leather determination and waste disposal were also summarized. Finally, the prospect and difficulty of SF-CO2 industrialization were pointed out. It is necessary to deal with the key technology and economica...