Objective: Studies on the in vivo, in vitro metabolism and excretion of cinobufagin (CB) which is the major active component in Traditional Chinese Medicine Chansu are aim to reveal the major biological active derivative(s) of cinobufagin in vivo.
Methods: (1) In vivo experiments: investigation of the biliary excretion of cinobufagin in rat; (2) In vitro experiments: investigation of the comparative metabolism of cinobufagin in liver microsomes from human and usual experimental animals including mouse, ...
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