Objective To investigate the protective effects of trans-resveratrol (TR) on Aβ25-35 induced dementia rats and its mechanism.
Methods After being trained by Morris water maze(MWM), rats were randomly divided into 6 groups:(1) sham-operated-group, (2) model-group, (3) TR low dose group, (4) TR middle dose group, (5) TR high dose group and (6)Aricept group. Dementia model was made by injecting Aβ25-35 to bilateral hippocampus of rats. Group (3)-(5) were treated with TR and aricept after the model was esta...