Colorectal cancer is one of the common cancers. Since it starts hiddenly and clinical manifestation is unspecific, about 40 percent of patients have occurred transference when they are diagnosed. For patients with distant metastasis and/or recurrence of postoperative, they should get palliative treatment which takes the chemotherapy as the main mean, its purpose is to enhance the patients'life, imprve the quality of their life and meliorate symptoms. But as the time of chemotherapy gets longer, the reaction...