Exothermic reaction runaway, one of the main causes of fluid equipment overpressure, is widespread in the petrochemical process, the resulting high temperature and pressure of which would lead to explosive destruction of pressure vessel. Since the 1980s, DIERS (Design Institute of Emergency Relief System) invested a lot in this field, and then a set of vent sizing methodology for exothermic reaction runaway has been gradually established. However, the result of the methodology is often conservative, sometim...