Objective
To research bioavailability and metabolism in Vitro for a new dosage form of TanshinoneⅡA ,a monomer composition from Salvia miltiorrhiza by developing a LC-MS/MS and in Vitro method, which will provide information for clinical application.
Methods
①Metabolism stability of TS was studyed with rat liver microsomes. In this investigation, the samples were incubated in 96-wells microtiter plate, proces sed with tert-butylether extraction and simultaneously detected by LC-MS/...
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