In this work,the research work of interactions between small molecules and serum albumin in recent years has been reviewed and the interaction between some drugs with bovine serum albumin(BSA) was studied.Spectroscopic techniques are widely used in analytical chemistry, however,the spectroscopic investigation combined with chemometrics,particularly for the interaction of small molecules and macromolecules,are relatively few.The application of chemometrics method-parallel factor analysis(PARAFAC) and...