目的:痛风性关节炎(gouty arthritis)是由于尿酸钠微结晶沉积在关节周围组织引发的急性炎症反应,以关节红、肿、热、痛和功能障碍为主要表现,临床常反复发作,日久可导致关节畸形。目前国内诸多学者在中医方药治疗痛风方面取得了一定的成果,但是纵观国内外文献资料,并未见1剂中药即取得显著治疗效果的报道。本实验根据Coderre介绍的尿酸钠诱导的大鼠足肿胀模型略作改进,通过观察西药秋水仙碱与中药痛风饮1剂对痛风性关节炎大鼠的患肢压力积分、步态、足肿胀度,白细胞、中性粒细胞、尿酸、白细胞介素-1β、白细胞介素-6在痛风性关节炎大鼠血清中的表达,以及对病理结构的影响,探讨中药痛风饮1剂在治疗急性痛风性关节炎中的药理作用,为中药治疗急性痛风性关节炎提供实验依据。
方法:
(1)选用48只Wistar大鼠,随机分成4组,每组12只,分别为空白对照组(Normal control group,N),秋水仙碱阳性对照组(Colchicine group,C),中药痛风饮治疗组(Tongfengyin group,T),模型组(Model group,M)。其中C、T、M组均于右踝关节腔内注...
【英文摘要】
Objective: Gouty arthritis due to crystals of monosodium urate deposition in the tissues around joints caused by acute inflammatory response. The main performance of joint is red, swelling, heat, pain and dysfunction, repeated attract. Now many scholars in the domestic Chinese herbs gout treatment has been got some achievements, but throughout literature, and there is not the report made significant treatment on a traditional Chinese medicine. According to Coderre on this experiment urate sodium crys...