Mass spectrometry techniques, especially soft ionization mass spectrometry and itsassociated technique, have been proved to be one of the most powerful tools in the analysis oflarge bio-molecules and traditional Chinese medicines due to the high sensitivity, speed,resolution and low levels of sample consumption. High performance liquid chromatography(HPLC) techniques, comparing with other methods, have the advantages of high columnefficiency, sensitivity, separation speed. It has been applied wide...