Esophageal cancer is one of the most deadly cancers in China and the mortality rate of esophageal cancer ranks the fourth. According to the present studies, the esophageal cancer is known as the polygene hereditary disease, and the environmental factors play a very important role. Therefore, it is important to study the genetic susceptibility and environmental risk factors and the gene-environment interaction on esophageal cancer, in high-incidence areas for definitude of pathogenesis of esopha...