Olopatadine Hydrochloride, a new H_1 receptor antagonist, was approved to go to the market in USA in 1997. It is considered to have a high affinity for histamine H_1 receptor and no effect on alpha-adrenergic and serotonin receptors.
In this thesis the synthetic method of Olopatadine Hydrochloride was studied. Olopatadine was synthesized by six steps. The yield of the Wittig reaction was raised from 61% to 78%. The separate method of E/Z isomers was simplified. The total yield of the six-step rea...
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