1. Determination of trans-resveratrol(t-Res) and trans-piceid(t-PD) in rat plasma by HPLC and their pharmacokinetics
Objective: To establish methods for the determination of t-Res and t-PD in rat plasma by HPLC. And to investigate and compare with the pharmacokinetic parameters of t-Res and t-PD in rats.
Methods: The Sprague-Dawley(SD) rats were divided into 3 groups randomly, sixty in each group. Each group was taken with different oral doses of t-Res (29.2, 58.5, 116.9mgkg~(-1) ). B...