Backgroud The sympathetic nervous system plays a crucial role in the cardiovascular disease such as hypertension and cardiac arrhythmia. Through the inhibition of β -adrenergic receptors in heart and kidney, β -blockers lower high pressure via the reduced response to the sympathetic nervous systems. But despite great success with traditional therapy , there are still many patients with poorly controlled high blood pressure and target organs dysfunction due to side effects including central nervous system re...