Objective: To research the optimal extraction conditions of polysaccharide from Angelica sinensis.Methods: Response surface methodology(RSM) was applied to optimize the best extraction conditions,and then verified the optimal conditions.Results: The optimal conditions were as follows: the time for 2.15 h,solid-liquid ratio at 1:8.27,and extraction times for 3 times.Conclusion: It is feasible to optimize the extraction processing of polysaccharide from Angelica sinensis by RSM.