Therapeutic Efficacy of a Recombinant Mycobacterium smegmatis Expressing an HBHA and hIL12 Fusion Protein Against Mycobacterium tuberculosis Infection Induced in Mice
Tried to investigate whether the HBHA-hIL12-rMS constructed could be effective as treatment against established infection,mice were infected with the H37Rv strain via the tail vein.Four weeks after infection,the mice were were treated with HBHA-hIL12-rMS.Determination of bacterial burden and histopathology were performed at 8 weeks post-infection.The HBHA-hIL12-rMS decreased lung bacterial load in lungs and reduced lung damage compared to the saline,although cannot achieve therapeutic drug levels.The HBHA-h...
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