[Objective]The research aimed to establish the obesity model of ICR mice and compare the morphological differences of adipose tissue between obese mice and control mice.[Method]Taking ICR mice as the study objects,the obesity model was established by feeding high-fat diet.The body weight,wet weight of adipose tissue and fat coefficient of ICR mice were determined and the morphological comparison of adipose tissue was made.[Result]The success rate of the obesity model of female and male mice were 16.67% and ...