MicroRNA-21(miR-21) is frequently up-regulated in cancer and the majority of its reported targets are tumor suppressors.Through functional suppression,miR-21 is implicated in practically every walk of oncogenic life:the promotion of cell proliferation,invasion and metastasis,genome instability and mutation,inflammation,replicative immortalization,abnormal metabolism,angiogenesis,and evading apoptosis,immune destruction,and growth suppressors.In particular,miR-21 is strongly involved in apoptosis.In this art...
【英文摘要】
MicroRNA-21(miR-21) is frequently up-regulated in cancer and the majority of its reported targets are tumor suppressors.Through functional suppression,miR-21 is implicated in practically every walk of oncogenic life:the promotion of cell proliferation,invasion and metastasis,genome instability and mutation,inflammation,replicative immortalization,abnormal metabolism,angiogenesis,and evading apoptosis,immune destruction,and growth suppressors.In particular,miR-21 is strongly involved in apoptosis.In this art...
【基金】
supported by the Diabetes and Obesity Center funded by NCRR/NIH(P20RR024489);
the Center for Environmental Genomics and Integrated Biology fundedby NIEHS/NIH(P30ES014443);
the Scientist Development Grant from American Heart Association(0830288N);
a R01 grant from National Institutes of Health(CA138688)
【更新日期】
2011-06-29
【分类号】
R730.2
【正文快照】
MicroRNAs(miRNAs)are small ribonucleic acidmolecules21to25nucleotides in length.Aftertranscription as primary miRNAs,they are processed intoprecursor miRNA(pre-miRNAs)by the enzyme Drosha,exported from the nucleus by exportin-5and furtherprocessed into th
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