Objective:To optimize the extraction conditions of flavonoids from Mosla dianthera Maxim. Method:We take the solvent quantity,extraction time and times of extraction as investigation factors to extract the total flavonoids determined by the method of spectrophotometry. The procedure for the extraction was performed with the extraction yield of total flavonoids as the response. Response surface method (RSM) was applied to determine the optimum extraction technology. Results:The optimum extraction condition w...