The transcatheter arterial chemoembolization(TACE)-based comprehensive treatment measures are the primary means of current treatment of hepatocellular carcinoma.TACE,however,can not completely kill the tumor cells,and repeated treatment can promote angiogenesis and increase the chance of tumor recurrence and metastasis.Patient survival time is still not satisfactory.In recent years,the emergence of molecular targeted drugs to treat hepatocellular carcinoma provides a new idea,has become one of the hot compr...