Objective To study the anti-fatigue effect of the water extract of Acanthopanaxsenticosusfruits and its mechanism,and provide experimental basis for exploration and utilization Acanthopanax senticosus resources. Methods Acanthopanax senticosus fruits were extracted by ultrasonic method and their aqueous extract was prepared.The mouse models of anti-fatigue were randomly divided into negative control,positive control and different doses of aqneous extract from Acanthopanax senticosns fruits groups.The anti-f...