Based on uniform design and support vector regression, UD-SVR, a novel experimental design and analysis method for the prescription optimization was proposed.It was applied to optimize the complicated fermentation medium including nine factors for a variant of Escherichia coli.The variant could produce glutamate decarboxylase which transformed gultamic acid into gamma aminobutyric acid in vitro.The optimization results of the medium by UD-SVR showed that OD630, an activity index of glutamate decarboxylase, ...
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