Runx2 is a member of the Runt homology domain family of transcription factors.As a specific transcription factor for osteocytes,Runx2 plays an important role in the formation and reconstruction of bone tissue.It can determine the differentiation of multipotent stem cells into osteoblastes,promote the maturity of chondrocytes and vascularization of cartilage.Runx2 is also associated with the formation of osteoclasts and intracellular matrix,the marrow endothelial cell migration and infiltration,the blood ves...