Bcl-2 family is the earliest factors that studied apoptosis-related.The role of Bcl-2 family members are anti-apoptosis or pro-apoptosis.Bcl-2 family members are important mitochondrial molecules regulating many aspects of mitochondrial physiology.Recently,the researches on Bcl-2 family had made great progress.Interestingly,some Bcl-2 family members not only play a role in cell apoptosis but also regulate cell cycle,so they couple apoptosis and cell cycle control in unique ways.The review is exactly to summ...