Capillary electrophoresis(CE)coupled with electrochemiluminescence(ECL)detection(CE-ECL)has been de-veloped into an important analytical tool,which has been widely used in the fields of food,environmental,pharmaceuti-cal and clinical analysis due to its simplicity,high sensitivity,powerful separation efficiency,inexpensive instrumenta-tion,and small sample volume.In this paper,the development of CE-ECL was critically reviewed,and the mechan-ism,modes,and application of CE-ECL in real samples were presented.