Objective: To observe the efficacy and toxicities of using oxaliplatin (L-OHP) combined with Cf and 5-FU in the treatment of advanced large intestine cancer. Methods: 47cases were diagnosed as advanced large intestine cancer by pathology, L-OHP 130mg/m2 ivgtt,3h.day1,CF200mg/day ivgtt 3h,day1-5;5-FU 500mg/ m2 ivgtt 6-8h,day1-5;every three weeks, after three cycles. The efficacy and toxicity interval of one month were evaluated. Results: The overall response rate was 40.4%, 2 cases are CR, 17 cases are PR. T...