The paper aimed to review and update the studies on umbilical cord blood mesenchymal stem cells (UCMSCs) by retrieving Pubmed database and Chinese Journal Full-text Database. As a pluripotent stem cell, UCMSC exhibits abundant source, simple collection, preservation and transport with no allograft injection or ethical issues. UCMSCs can differentiate into cells of hematopoietic system and into osteoblast, chondrocyte, adipocyte, myocyte, neurocyte and hepatocyte under specific culture conditions. UCMSC surf...