AIM:To investigate the expression of SOCS1 and STAT3 in hepatocellular carcinoma(HCC), as well as their significance in the occurrence and development of HCC. METHODS:The expression of SOCSland STAT3 proteins were examined by immunohistochem- istry in 48 tissue specimens from HCC and their para-carcinoma tissues,11 from liver cirrhosis tissues,and 11 from normal liver tissues. RESULTS:The positive rate of SOCS1 ex- pression was significantly higher in the para- carcinoma tissues than in the HCC tissues(P<0....